Teaching Case 2

49 y/o F with presents with a left breast palpable area. What is the most likely diagnosis?

unk ilc 1
unk ilc 2


  • 5-10% of breast cancers
  • Distinct from invasive ductal carcinoma
  • More often multicentric and bilateral (10-15%)
  • Loss of E-cadherin (biomarker) **
  • Cells of ILC often preserve the architecture of the ducts, which limits the sensitivity of detection using mammography
  • Mammo: “Shrinking breast” or reduced compressibility
  • US: ill-defined hypoechoic mass

Related Radiology Article: Lopez JK, Bassett LW. Invasive lobular carcinoma of the breast: spectrum of mammographic, US, and MR imaging findings. Radiographics. 2009 Jan;29(1):165-76.