INVASIVE LOBULAR CARCINOMA

• 5-10% of breast cancers
• Distinct from invasive ductal carcinoma
• More often multicentric and bilateral (10-15%)
• Loss of E-cadherin (biomarker) **
• Cells of ILC often preserve the architecture of the ducts, which limits the sensitivity of detection using mammography
• Mammo: “Shrinking breast” or reduced compressibility
• US: ill-defined hypoechoic mass

Related Radiology Article: Lopez JK, Bassett LW. Invasive lobular carcinoma of the breast: spectrum of mammographic, US, and MR imaging findings. Radiographics. 2009 Jan;29(1):165-76.