Teaching Case 2
49 y/o F with presents with a left breast palpable area. What is the most likely diagnosis?
INVASIVE LOBULAR CARCINOMA
- 5-10% of breast cancers
- Distinct from invasive ductal carcinoma
- More often multicentric and bilateral (10-15%)
- Loss of E-cadherin (biomarker) **
- Cells of ILC often preserve the architecture of the ducts, which limits the sensitivity of detection using mammography
- Mammo: “Shrinking breast” or reduced compressibility
- US: ill-defined hypoechoic mass
Related Radiology Article: Lopez JK, Bassett LW. Invasive lobular carcinoma of the breast: spectrum of mammographic, US, and MR imaging findings. Radiographics. 2009 Jan;29(1):165-76.